Cyanobacterial crowding-out effects on metabolite partitioning: modeling 2-methylisoborneol (MIB) release dynamics and implications

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AI介绍

摘要

2-甲基异莰醇（MIB）是一种强效蓝藻代谢物，在痕量浓度下即可通过异味问题影响饮用水水质。尽管其影响显著，但MIB的胞内动力学及环境释放机制仍鲜有研究。我们通过对两种产毒菌株的受控实验，建立了一个生长阶段依赖的MIB释放机理模型。该模型揭示，胞外MIB比例（\(f = e_{MIB}/t_{MIB}\)）遵循一致模式：在对数生长中期降至最低，随后在稳定期上升并稳定在0.4至0.6之间，表明拥挤诱导的细胞裂解驱动了释放动态。将该模型应用于太湖，成功重构了2022-2023年间的两次异味事件，阐明了MIB生产者时空动态，并确定了在中等光照（0.1-0.4 mol m⁻² d⁻¹）下约15°C和>30°C的关键风险阈值——这些模式是常规监测无法发现的。我们的研究结果表明，生理阶段转换而非仅生物量积累控制着异味物的释放。该框架可扩展至其他藻类代谢物（如土臭素、蓝藻毒素），提供更广泛的预测能力。通过将细胞过程与水质风险相关联，我们的方法能够实现对蓝藻污染物的主动管理，为早期预警系统和氧化剂类型优化的运行指导提供信息，以防止藻细胞中有害化合物的大规模释放。

图形摘要

内容概览

Modeled relationships between inflection point time (\(T{IP}\)), MIB risk, and environmental drivers in Lake Taihu: (A) Mechanistic model outputs showing \(T{IP}\) as a function of water temperature, underwater light dose (\(I\)), and initial cell density (\(N0\)); (B) Estimated probability of MIB concentrations exceeding the 10 ng L-1 threshold under identified high-risk conditions.

Modeled relationships between inflection point time (\(T{IP}\)), MIB risk, and environmental drivers in Lake Taihu: (A) Mechanistic model outputs showing \(T{IP}\) as a function of water temperature, underwater light dose (\(I\)), and initial cell density (\(N0\)); (B) Estimated probability of MIB concentrations exceeding the 10 ng L-1 threshold under identified high-risk conditions.

Modeled relationships between inflection point time (\(T{IP}\)), MIB risk, and environmental drivers in Lake Taihu: (A) Mechanistic model outputs showing \(T{IP}\) as a function of water temperature, underwater light dose (\(I\)), and initial cell density (\(N0\)); (B) Estimated probability of MIB concentrations exceeding the 10 ng L-1 threshold under identified high-risk conditions.

Schematic representation of MIB allocation dynamics influenced by cell crowding, both intracellularly and extracellularly

引用与导出

@article{ai2025cyanobacterial,
  title = {Cyanobacterial crowding-out effects on metabolite partitioning: modeling 2-methylisoborneol (MIB) release dynamics and implications},
  journal = {Journal of Hazardous Materials},
  pages = {140118},
  volume = {499},
  year = {2025},
  issn = {0304-3894},
  doi = {10.1016/j.jhazmat.2025.140118},
  url = {https://www.sciencedirect.com/science/article/pii/S0304389425030377},
  author = {Yufan Ai^#^ and Yongnian Wu^#^ and **Ming Su**^\*^ and Yuying Gui and Yifan Du and Jiao Fang and Tengxin Cao and Min Yang},
  keywords = {2-methylisoborneol (MIB), Cell lysis-mediated release, Drinking water early warning, Growth-phase dependent release, Taste and odor}
}